Introduction. Medicinal products based on plant raw materials have always been in great demand, they were the first medicinal products and do not lose their popularity to this day, as in most cases they have a number of advantages over their possible synthetic counterparts.
Therefore, the expansion of research devoted to the search for new sources for obtaining safe and effective herbal medicinal is an urgent direction of modern pharmacology.
Research can be focused both on the search for new sources of active pharmacological ingredients, and on the implementation of extended research on plant materials already known for their pharmacological activity. In the second case, in turn, there are also a lot of urgent, still unresolved problems. In particular, there is always a need to carry out technological optimization of various stages of drug development (extraction of active substances from plant raw materials, development of various dosage forms, research of their pharmacokinetic and pharmacodynamics features) and establishment of both the spectrum of their pharmacological activity and concomitant and side effects.
The object of the research was plant raw material - large-flowered jasmine, which belongs to the genus Jasmine, the Olive family.
The aim of the work was the technological development of a complex extract of large-flowered jasmine and its standardization.
Materials and methods. For the study, dry plant material was used - the flowers of large-flowered jasmine, for which the residual moisture indicators were additionally determined according to the standard method (it was 6.97%).
To obtain the extract, the raw materials were ground to a particle size of 2-3 mm. The Soxhlet apparatus was filled with crushed raw materials (pre-weighed). As an extractant in the first case, 50% ethyl alcohol was used, in the second case, 50% methyl alcohol in a ratio of 1:5. Each series of extractions was carried out for 3 hours. After that, the extracts were poured into measuring cylinders, the resulting volume was noted, transferred to a rotary evaporator, the extractants were driven off, and the obtained extract-concentrates were weighed.
After that, the obtained extracts were combined and a complex extract-concentrate was obtained. Standardization of the extract-concentrate was carried out according to the content of the sum of polyphenolic compounds in terms of gallic acid, using the Folin-Chocolteau method.
Results and their discussion. According to the results of the research, it was established that the concentration of the sum of polyphenolic compounds is 35.52 mg/ml (or 32.72 mg/g) of the obtained complex extract of large-flowered jasmine flowers.
In the future, the obtained results can be used in the development of a recipe for medical and cosmetic products, using the obtained standardized extract as an active ingredient.
Conclusions. Thus, the technology of obtaining a complex extract-concentrate was presented and its standardization was carried out according to the content of the sum of polyphenolic compounds.
Keywords. Extraction, Soxhlet apparatus, complex extract.
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